Analysis of the algorithm: From rankings to backup genes.

Ranking section

For each of the affected genes present in the list, a ranking with the score and percentile of every possible gene was obtained. Once this was done, the position for every known backup gene was obtained and the statistical descriptor of all the values calculated.

Table 1. Backup position values for every kernel and net before integration.

Net Kernel Elements Min Max Average Standard_Deviation
biological_process ct 57 0.0 0.577 0.052 0.113
biological_process el 57 0.06 0.966 0.628 0.239
biological_process ka 57 0.0 0.613 0.049 0.113
biological_process rf 57 0.0 0.577 0.052 0.113
cellular_component ct 57 0.0 0.812 0.095 0.162
cellular_component el 57 0.0 1.0 0.535 0.308
cellular_component ka 57 0.0 0.814 0.098 0.165
cellular_component rf 57 0.0 0.812 0.095 0.162
disease ct 16 0.002 0.945 0.242 0.316
disease el 16 0.005 0.935 0.325 0.297
disease ka 16 0.0 0.756 0.226 0.286
disease rf 16 0.002 0.943 0.242 0.316
genetic_interaction ct 51 0.0 1.0 0.41 0.338
genetic_interaction el 51 0.0 1.0 0.406 0.334
genetic_interaction ka 51 0.0 0.302 0.13 0.081
genetic_interaction rf 51 0.0 1.0 0.41 0.338
molecular_function ct 57 0.0 0.797 0.076 0.187
molecular_function el 57 0.02 0.954 0.429 0.296
molecular_function ka 57 0.0 0.773 0.075 0.186
molecular_function rf 57 0.0 0.797 0.077 0.187
pathway ct 27 0.0 0.996 0.066 0.188
pathway el 27 0.0 0.185 0.027 0.048
pathway ka 27 0.0 0.127 0.016 0.028
pathway rf 27 0.0 0.157 0.027 0.043
phenotype ct 17 0.0 0.881 0.265 0.301
phenotype el 17 0.176 0.837 0.481 0.186
phenotype ka 17 0.0 0.938 0.29 0.328
phenotype rf 17 0.0 0.879 0.264 0.3
protein_interaction ct 59 0.0 0.349 0.021 0.062
protein_interaction el 59 0.0 0.39 0.018 0.057
protein_interaction ka 59 0.0 0.032 0.002 0.005
protein_interaction rf 59 0.0 0.325 0.02 0.06

Table 2. Backup position values for every kernel after integration

Integration Kernel Elements Min Max Average Standard_Deviation
integration_mean_by_presence ct 59 0.0 0.728 0.071 0.173
integration_mean_by_presence el 59 0.0 0.855 0.148 0.189
integration_mean_by_presence ka 59 0.0 0.811 0.052 0.153
integration_mean_by_presence rf 59 0.0 0.32 0.022 0.057
mean ct 59 0.0 0.681 0.053 0.151
mean el 59 0.0 0.743 0.084 0.148
mean ka 59 0.0 0.587 0.036 0.101
mean rf 59 0.0 0.323 0.028 0.07

CDF plots of non integrated kernels

CDF plots of integrated kernels